A remarkable new study from Memorial Sloan Kettering Cancer Center—a world-renowned research institution—has unveiled a powerful role for alpha-ketoglutarate (AKG) in tissue regeneration. The findings, recently published in Nature, the highest-impact scientific journal in the world, suggest that this key metabolite could be a game changer for gut health, chronic inflammation,...

This article summarizes research findings on the health-beneficial effects of α-ketoglutarate in maintaining intestinal homeostasis and explores
the associated underlying mechanisms.

Introduction: Alpha-ketoglutarate (AKG) is a naturally occurring metabolite that plays a central role in cellular metabolism. In recent years, there has been growing interest in the potential role of AKG in regulating fertility and fecundity. Animal studies have shown that AKG supplementation can improve fertility in both males and females,...